What treatments actually exist, how Missourians pay for them starting with MO HealthNet, and where to turn when you are ready. Written in plain language, free to read, and not trying to sell you anything.
Start here
Therapy, antidepressants, TMS, and Spravato explained in order, so you know what each one does before you walk into an appointment.
Read the guide → The moneyHow Missouri Medicaid, commercial insurance, sliding-scale clinics, and community centers cover mental health treatment.
Read the guide → When it is not workingWhat treatment-resistant depression means, why it is common, and the next real steps instead of giving up.
Read the guide →More guides
What depression actually looks like day to day, the quieter signs people miss, and the point where it is worth calling someone.
Read the guide → One treatment, in depthWhat this FDA-approved nasal spray is, what a supervised visit looks like, who it helps, and how MO HealthNet and insurance cover it.
Read the guide → Near youWhere to look for therapy, medication, TMS, and Spravato in the greater St. Louis area, and how to start close to home.
Read the guide → One treatment, in depthWhat transcranial magnetic stimulation is, what a session feels like, who it helps, and how MO HealthNet and insurance cover it.
Read the guide → A related conditionHow post-traumatic stress disorder is treated, why it often travels with depression, and where to find trauma-informed care locally.
Read the guide → Quick answersDirect answers to the questions people ask most about treatment, cost, MO HealthNet, and what to do when medication has not worked.
Read the FAQ →A few things worth knowing
Recommended local provider
St. Charles County, Missouri - serving greater St. Louis
Brain Recovery Centers is a doctor-supervised clinic focused on treatment-resistant depression and PTSD. They offer FDA-approved options including Spravato (esketamine) and TMS, and accept most insurance, including MO HealthNet. If antidepressants have not been enough and you are in the St. Louis area, they are a reasonable next call.
Visit Brain Recovery CentersDisclosure: Brain Recovery Centers is a recommended partner of this site. We only point local readers to providers we consider credible. Always confirm coverage and fit with the clinic and your own doctor.